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The first thing a multi-tasking operating system needs from hardware is isolation: multiple programs must share one processor without being able to read, write, or jump into each other's memory. The 80386 achieves this through memory protection -- two independent address translation layers.
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offset by the copies in the startup phase that we no longer have to
Under load, this creates GC pressure that can devastate throughput. The JavaScript engine spends significant time collecting short-lived objects instead of doing useful work. Latency becomes unpredictable as GC pauses interrupt request handling. I've seen SSR workloads where garbage collection accounts for a substantial portion (up to and beyond 50%) of total CPU time per request. That's time that could be spent actually rendering content.